BIOLOGICAL ACTIVITIES, PHENOLIC CONSTITUENTS AND OF VARIOUS EXTRACTS OF CYCLAMEN COUM TUBERS AND LEAVES FROM TURKEY

The present study evaluated thephenolics composition and biological activities of various extracts Cyclamen coum. antioxidant properties these plant wasdetermined using the scavengingmethods (DPPH andABTS), total test systems (β-carotene/linoleic acid), reducing power (FRAP) assays.The antibacterial effect was examined with MIC method. phenolics were identified HPLC brine shrimp lethality used to screen for possible toxicity. Larvicidal activity against Cx. pipienswas assessed.The highest phenolic compound foundcinnamic acid 411.6 µg/g. flavonoid found in ethanolic 8.99±3.07 mgGAE/mL 54.66±3.02 mgQE/g, respectively. tuber-methanol extract exhibited capacity test, 76.43±3.02%). radical scavinging varied from 129.74±0.02 (tuber ethanol) 336.3±0.02 acetone) IC50 μg/mL assay) 118.04±0.07 321.96±0.08 (leaves (ABTS assay). Very strong reduction Gr (+) S. aureus growth observed during incubation tubermethanolic (MIC 56±0.03μg/mL). assay tubermethanol has showed good cytotoxic LC50 3.016 μg/mL. tuber C. Coum larvicidal pipiens value (296.80 μg/mL). C.coum could be a source derive potential agents. However, further studies are needed determine mechanism involved process.